I was inspired by all the Substance spheres to go ahead and make the most deadly substance in the galaxy! I challenged myself to keep everything to only Substance Designer and a sphere. I ended up with a 8K map but could have gone up to 16k had Substance allowed. In the future maybe UDIMs would be the way to go, but it was fun to try to do everything in Substance Designer. I baked out the maps and rendered the first image with 3ds Max and Vray.
Substance Maps Output: